Why Your Muscles Might Feel Weaker — and What You Can Do About It

Statins save lives — but they can sap your strength

Statins are the most commonly prescribed medications in the U.S., helping millions lower their cholesterol and protect their hearts. But if you've noticed more muscle soreness, fatigue, or weakness since starting a statin, you're not alone — and there's a scientific reason behind it.

How statins work — and why they affect muscle energy

Statins block an enzyme called HMG-CoA reductase, which your body uses to make cholesterol. That same enzyme also helps your body produce Coenzyme Q10 (CoQ10) — a key nutrient your muscles need to generate energy in their mitochondria. When CoQ10 levels drop, your muscles have a harder time producing energy efficiently. The result? Fatigue, soreness, or slower recovery — symptoms that can affect anyone, but especially active adults and golfers who rely on smooth, powerful movement.

The evidence for CoQ10 supplementation

Multiple studies and meta-analyses have shown that supplementing with CoQ10 can help reduce statin-associated muscle symptoms (myopathy), with doses of 100–300 mg per day most commonly studied. A 2021 review in the Journal of the American Heart Association found CoQ10 supplementation significantly improved muscle pain and weakness scores compared to placebo. A 2018 meta-analysis in Atherosclerosis showed CoQ10 reduced muscle-related side effects without interfering with the cholesterol-lowering effects of statins. CoQ10 is safe, well-tolerated, and doesn't interact negatively with statins — for most people, it's an easy addition to their daily routine.

Which form is best?

There are two main forms of CoQ10: ubiquinone (oxidized) and ubiquinol (reduced, more absorbable). For older adults or anyone taking statins, the ubiquinol form is often absorbed more efficiently and delivers better results. It works best taken with a meal that includes healthy fats. Freshly ground black pepper contains piperine, which greatly enhances absorption — but it loses potency quickly, so pre-ground pepper won't have the same effect.

Why this matters for golfers and active adults

If you're a golfer or athlete, your muscles rely on consistent mitochondrial energy production for rotation, stability, and recovery. Low CoQ10 levels can make you feel sluggish — the opposite of what you want in your swing or training. Replenishing CoQ10 helps boost energy and endurance, reduce soreness and fatigue, support cognitive and cardiovascular health, and keep you performing at your best on and off the course.

The Taylor Made approach

At Taylor Made Integrative Therapy, we combine clinical insight with performance-focused care. If you're on a statin and feeling weaker, slower, or more fatigued than usual, CoQ10 might be a missing link in your recovery and performance plan. "Statins protect your heart, but your muscles need protection too."

Always talk with your healthcare provider before starting a new supplement, especially alongside prescription medications.

Dr. Jeremy Taylor, DC

Sports Chiropractor · TPI Medical 3 Certified

Dr. Taylor is a TPI-certified sports chiropractor at Taylor Made Integrative Therapy in Fort Worth, TX. He helps golfers, athletes, and active adults move better, feel better, and perform at their best — by fixing the movement issues underneath the pain. More about Dr. Taylor →